I have previously blogged about hepatitis and tylenol overdose here and here.
The article the discussant mentioned on alcohol and tylenol overdose is available here. There is a newer publication that looks retrospectively at 20 years of ingestion data and adjusts the classic Rumack-Matthew nomogram for chronic alcohol use (without simultaneous co-ingestion).
A similar study proposes to predict the risk of hepatotoxicity using a combination of the tylenol level, the time since ingestion, and the time N-AC is started.
There is some evidence that simultaneous co-ingestion may be protective. This effect, and the effect of alcohol are quantified in the table here (based on the above nomogram)
A good review article on alcoholic hepatitis is available here.
Other groups have suggested that the glascow alcoholic hepatitis score >=9 is more useful in predicting benefit from corticosteroids than the DF.
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