Wednesday, February 11, 2009

Day #216 - Acute Interstitial Nephritis


We talked about a case of a patient with an acute rise in creatinine to the 600's from a baseline of 50 in the context of adding new medications. The patient developed eosinophilia and white blood cell casts compatible with a diagnosis of interstitial nephritis.

The types of interstitial nephritis are shown (above).

A similar case is presented in the NEJM here with associated discussion. This was also a case of presumed drug induced AIN. Some of the more common causes are listed (above)

A more detailed review on drug induced AIN is available here.

The role of urine eosinophils (i.e. maybe there shouldn't be a role) in this diagnosis is reviewed here.

I've previously blogged about renal failure (and linked to good articles) here.

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